Genetic variants of methionine metabolism and DNA methylation

Genetic variants of methionine metabolism and DNA methylation.

AIM Altered DNA methylation is associated with important and common pathologies such as cancer. The origin of altered DNA methylation is unknown. The methyl groups for DNA methylation are provided by methionine metabolism. This metabolism is characterized by a high interindividual variability, which is in part explained by genetic variants. METHODS In a cohort of 313 individuals derived from ...

Altered methionine metabolism, DNA methylation and oncogene expression in carcinogenesis. A review and synthesis.

Methionine increases BDNF DNA methylation and improves memory in epilepsy

OBJECTIVE Temporal lobe epilepsy (TLE) patients exhibit signs of memory impairments even when seizures are pharmacologically controlled. Surprisingly, the underlying molecular mechanisms involved in TLE-associated memory impairments remain elusive. Memory consolidation requires epigenetic transcriptional regulation of genes in the hippocampus; therefore, we aimed to determine how epigenetic DNA...

Discovering DNA motifs and genomic variants associated with DNA methylation

DNA methylation plays a crucial role in establishing tissue-specific gene expression. However, our incomplete understanding of the cis elements that regulate DNA methylation prevents us from interpreting the functional effects of non-coding variants. We present CpGenie (http://cpgenie.csail.mit.edu), a deep convolutional neural network that learns a regulatory sequence code of DNA methylation a...

The relative contribution of DNA methylation and genetic variants on protein biomarkers for human diseases

Associations between epigenetic alterations and disease status have been identified for many diseases. However, there is no strong evidence that epigenetic alterations are directly causal for disease pathogenesis. In this study, we combined SNP and DNA methylation data with measurements of protein biomarkers for cancer, inflammation or cardiovascular disease, to investigate the relative contrib...